STUDIES OF NEUROMUSCULAR FUNCTION
Interim progress rept., 1 Jan-30 June 1961
JOHNS HOPKINS UNIV BALTIMORE MD INST FOR COOPERATIVE RESEARCH
Pagination or Media Count:
Investigations are in progress to determine the nature of the block in neuro-muscular transmission produced by depolarizing substances such as acetylcholine, which accumulates at the motor end-plate region in anticholinesterase intoxication. The study of the mechanism of block produced by anticholinesterase agent has been modified so that anticholinesterase drug is administered in vivo and studies are made of serum and muscle electrolytes, neuromuscular transmission, muscle membr ne potential, and end-plate potential. If insignificant changes in serum electrolyte concentration occur, radio-sodium and radio-potassium will be used to determine the efflux rate by the pre-loading technique. Another investigation currently under way is the converse of t lerance to anticholinesterase drugs and depolarization, namely, increase susceptibility to the action of depolarizing substances.
- Anatomy and Physiology