Accession Number:

AD0260418

Title:

PATHOLOGICAL PHYSIOLOGY AND THERAPY OF LUNG INJURIES

Descriptive Note:

Corporate Author:

PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s):

Report Date:

1961-09-01

Pagination or Media Count:

1.0

Abstract:

The inhalation of steam in anesthetized dogs caused an increase in bronchopulmonary flow which is induced by a thermal constriction of the bronchial veins. The bronchial veins are more sensitive than the bronchopulmonary anastomoses to vasoconstrictors norepinephrine, serotonin, as well as to vasodilators. The bronchial arterial injection of histamine elicits a reflex mediated via the vagus, consisting of bronchoconstriction, bradycardia and hypotension. The various components of the bronchial circulation, pulmonary circulation and bronchial smooth muscles have been investigated as to their sensitivity to sympathomimetic drugs, sympathetic blocking agent bretylium and to digitalis. Many of the drugs prove to be effective in reversing the pathological disturbances seen in thermal injury to the lungs. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE