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THE EFFECT OF HIGH PROTEIN DIETS ON RENAL HYPERTROPHY IN RATS FOLLOWING WHOLE-BODY IRRADIATION
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF
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The relationship between high protein intake and increase in kidney weight was investigated in rats exposed to a single dose of 375 rad X-irradiation. Attempts were made to characterize the degree of renal hypertrophy and hyperplasia nvolved by employing irradiation as an inhibitor of cellular proliferation. Rats were fed a high protein diet and exposed to irradiation at various points of the feeding regime. The high protein diet significantly increased kidney weight in all cases but the increase was not influenced by the X-ray dose employed, or time of administration. However, histological studies of the kidneys showed that irradiation reduced the incidences of abnormal tubular hyperplasia. The renal lesions also appeared much earlier than previously reported by other investigators. Rats fed high protein diets appeared to recover body weight loss from the irradiation at a faster rate than those fed a basal diet. A possible mechanism is briefly discussed. Author
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