Erythropoietic Stimulating Factor Production in Pubescent Mice after a Single Exposure to Hypoxia.
NAVAL SCHOOL OF AVIATION MEDICINE PENSACOLA FLA
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When animals are exposed continuously to hypoxia, the following sequence of hematological events occurs production of erythropoietic stimulating factor ESF, reticulocytosis, and polycythemia. Humoral changes occur during the first day atALTITUDE, BUT IT IS NOT KNOWN HOW SOON EST is produced or whether it is produced equally by juveniles and adults alike. In this experiment these factors are investigated a ESF production after short-time hypoxic exposure and b ESF production under the same conditions in pubescent BDF1 mice. The results indicate that ESF is produced in this strain of mice after a six-hour exposure to 22,000 feet. It is further demonstrated that these mice have augmented response to hypoxia at the time of increased endocrine function at puberty. Author