Accession Number:

AD0258217

Title:

A STUDY OF THE SYNTHESIS OF 2-TRIFLUOROMETHYL PYRIMIDINES

Descriptive Note:

Corporate Author:

NAVAL ORDNANCE TEST STATION CHINA LAKE CALIF

Personal Author(s):

Report Date:

1961-12-01

Pagination or Media Count:

1.0

Abstract:

Phenylbutanedione-1,3 and 2,4-pentanedione were reacted with trifluoroacetamidine in the presence of sodium ethoxide. A crystalline product melting at 38.4 C was recovered from the reaction of 2,4-pentanedione and trifluoroacetamidine and tentatively identified by its IR spectra as 2-trifluoromethyl-4,6-diemthylpyrimidine. The reaction of trifluoroacetamidine and phenylbutanedione-1,3 in the presence of sodium ethoxide yielded a white crystalline product melting at 90.3 C which was also tentatively identified as the 2-trifluoromethyl4-methyl-6-phenylpyrimidine. The amidine of trifluoroacetic acid reacted in a manner described for the reaction of an amidine with a beta-diketone. Yields obtained 10-34 were within the limits reported for many other pyrimidine syntheses, influenced in part by the instability of trifluoroacetamidine. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE