Accession Number:

AD0257792

Title:

EFFECT OF PHOSPHORYLATED HESPERIDIN AND HYALURONIDASE ON THE RATE OF ERYTHROCYTE REMOVAL FROM THE PERITONEAL CAVITY OF RATS

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

Report Date:

1960-09-30

Pagination or Media Count:

1.0

Abstract:

Previously reported studies reveal that phosphorylated hesperidin interferes with absorption of 0.9 NaCl solution from the peritoneal cavity of rats, while hyaluronidase facilitzvates this process. In the present study the effect of phosphorylated hesperidin and hyaluronidase on absorption of erythrocytes from the peritoneal cavity was investigated. The absorption rate of erythrocytes from the peritoneal cavity of untreated rats was found to be similar to that reported in the literature, 80 of the red blood cells being removed within 8 hr after administration of the red blood cell suspension. Treatment with phosphorylated hesperidin significantly interfered with the absorption, only 12 of the originally administered erythrocytes being absorbed within the first 8 hr. Hyaluronidase increased the absorption slightly however this increase was statistically significant. Evidence was presented suggesting that phosphorylated hesperidin exerts its effect by decreasing the permeability of membranes separating the peritoneal cavity from the diaphragmatic lymphatics. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE