Accession Number:

AD0257791

Title:

DIVERSITY OF TRANSPLANTATION ANTIGENS IN THE MOUSE

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

Report Date:

1960-07-02

Pagination or Media Count:

1.0

Abstract:

When mice of one inbred strain are immunized by primary exposure to transplantation antigens from another strain, and subsequently challenged with homografts from a second donor strain, such grafts are frequently rejected prematurely, depending on the genetic relationships of the strains. The result can be taken as evidence that the primary and secondary donor strains share in common histocompatibility genes, hence the corresponding antigens, that the recipient lacks. All of the permutations 36 of primary donors, secondary donors and recipients possible with four strains of mice were tested for shared or related antigens. In this way it was possible to identify several antigenic factors and determine their distribution among the strains when spleen cell suspensions were used for primary immunization. When antigenic cell-free extracts were used for immunization fewer factors were in evidence. It was concluded that transplantation antigens are quite probably a diverse group of substances having distinct physical and chemical properties as well as antigenic specificities. The methodology of transplantation typing is discussed, and the findings are related to the diversity of hemagglutination factors controlled by the H-2 locus. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE