Accession Number:

AD0257595

Title:

EFFECT OF PROPYLTHIOURACIL TREATMENT AND ADRENALECTOMY ON HEAT PRODUCTION AND HEAT LOSS DURING ACUTE EXPOSURE TO COLD

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

Report Date:

1961-04-01

Pagination or Media Count:

1.0

Abstract:

Thyroidectomy propylthiouracil treatment and adrenalectomy increased rate of cooling of rats restrained and subjected to air at 5 C. At the same colonic temperature during cooling, both thyroidectomized and adrenalectomized rats maintained higher skin temperatures than did control rats. Heat production measured by oxygen consumption was determined for thyroidectomized and control rats only. At the same colonic temperatures during cooling thyroidectomized rats had the same heat production as controls. Calculation of heat loss at a given colonic temperature during cooling, however, revealed it to be greater for thyroidectomized than for control rats. The inability of thyroidectomized rats to tolerate cold as well as the control rats did under these conditions is due almost entirely to a more rapid loss of body heat. Failure to conserve heat may be related to changes in vascular reactivity induced by the hypothyroid state. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE