Accession Number:

AD0257578

Title:

PHARMACOLOGICAL STUDIES ON IRRADIATED ANIMALS. X. EFFECTS OF CELL-FREE SPLEEN EXTRACT TREATMENT ON HEMATOPOIETIC TISSUES OF IRRADIATED GUINEA PIGS

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

Report Date:

1960-11-04

Pagination or Media Count:

1.0

Abstract:

Qualitative and quantitative histological and histochemical evidence is presented which indicates that cell-free saline spleen extracts modify radiation induced changes in the spleen and bone marrow of guinea pigs following exposure to an LD7520 of Co60 gamma radiation. Postirradiation treatment with homologous or heterologous mouse spleen extract accelerates the natural recovery process of the spleen and bone marrow of guinea pigs, while the initial effect remains unchanged. Histological findings give the impression that this accelerated recovery process is due to a stimulatory effect of the spleen extract on stem cells. Histochemical studies indicate that spleen extracts also modify the radiation effect on the alkaline phosphatase staining cells of the spleen. Since homologous or heterologous extracts produce similar results, a common mechanism of recovery has been postulated. Study of the temporal sequence of changes indicates that recovery processes in spleen precede those in bone marrow, thus indicating a hierarchy of events. The significance of these findings for biology and clinical medicine is discussed. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE