Accession Number:

AD0257323

Title:

SERIAL CORRELATIONS OF THE CHEMICAL ANATOMY OF HEPATIC AND RENAL CELLS WITH ORGAN STRUCTURE AND CLINICAL STATUS IN MAN

Descriptive Note:

Corporate Author:

PRESBYTERIAN-ST LUKE'S HOSPITAL CHICAGO ILL

Personal Author(s):

Report Date:

1961-03-31

Pagination or Media Count:

1.0

Abstract:

Data on lactic dehydrogenase, glutamic oxalacetic transaminase, and sorbitol dehydrogenase have been obtained in the anatomical portions of the normal liver lobule in man. Data has been obtained on the enzyme activities of the various anatomical portions of the nephron in healthy dogs and man. The data has been compared with the findings in renal tubular acidosis and hepatolenticular degeneration. In addition, data has been obtained on healthy human kidneys after the production of metabolic acidosis by classical ammonium chloride loading techniques. The data suggests that carbonic anhydrase is not the key enzyme deficiency in renal tubular acidosis. In hepato-lenticular degeneration there were no significant abnormalities in glutamic oxalacetic transaminase, glutamic pyruvic transaminase, and glutamic dehydrogenase activities -- enzymes which might have been expected to be involved in a disorder with gross amino aciduria. Studies have also been done on antinuclear factors in the serum of patients with hepatic disease. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE