Accession Number:

AD0257292

Title:

RENAL CLEARANCE OF SODIUM AND POTASSIUM IN HYPOTHERMIA

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

Report Date:

1961-03-01

Pagination or Media Count:

1.0

Abstract:

The renal tubular handling of Na and K at various hypothermic levels was studied. Fourteen dogs were anesthetized with 30 mg.kg. of sodium pentobarbital. After suitable control clearance measurements, the rectal temperature was lowered progressively by ice-packing to about 25 C. while continuous renal clearance studies were carried out. Artificial respiration was not used. No change in plasma Na was detected but plasma K fell significantly from a control value of 4.1 mEq.liter or - 0.09 at 38 C. to 3.4 mEq.liter or - 0.12 at 25 C. Urine Na concentration fell during exposure to cold while K concentration showed a small increase. In spite of the marked fall in glomerular filtration rate 69.0 ml.min. or - 3.1 control to 17.0 ml.min. or - 3.6 at 25 C. the final urine flow at 25 C. was slightly greater than that of the control. The EF ratios ratio of excreted to filtered for Na, K, and H2O increased significantly, reflecting the marked decrease in general tubular reabsorption. The EF for H2O increased from O.49 or - 0.05 at 38 C. to 2.02 or 0.25 at 25 C., the EF for Na increased from 0.47 or - 0.12 at 38 C. to 1.13 or - 0.27 at 25 C., while the EF for K increased from 18.0 or - 2.6 at 38 C. to 54.0 or - 12.0 at 25 C. The variation in effect of hypothermia on the EF ratios is a reflection of the renal regulations occurring as well as the differing reabsorptive mechanisms. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE