Accession Number:

AD0257080

Title:

THE EFFECT OF MOLECULAR STRUCTURE ON CATALYSIS AND MOLECULAR BINDING

Descriptive Note:

Corporate Author:

WISCONSIN UNIV MADISON

Personal Author(s):

Report Date:

1961-03-01

Pagination or Media Count:

1.0

Abstract:

In the studies related to the catechol-Sarin reaction, the pH profile of the rate of hydrolytic cleavage of the reaction products has been experimentally determined over the entire pH range above four. Possible mechanisms consistent with these observations are presented. Rates of hydrolysis of a series of phenolate phosphonate analogues of Sarin were determined. Data are given for p-nitro, p-methoxy, and p-chloro esters as well as the simple phenyl ester. All systems exhibited first order dependency on OH-. Apparent heats of activation and entropy data have been obtained. Further data are reported on the remarkable catalytic activity of trans-cyclohexane 1,2-dicarbocylic acid on the hydrolysis of chloramphenicol. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE