Accession Number:

AD0257020

Title:

ANTI-RADIATION DRUGS DERIVED FROM SULFINAMIDES AND N-SULFINYLAMINES

Descriptive Note:

Corporate Author:

KENTUCKY UNIV LEXINGTON

Personal Author(s):

Report Date:

1961-06-01

Pagination or Media Count:

1.0

Abstract:

The possible preparation of N-sulfinyl derivatives of 2-aminoethanethiol and p-aminobenzenethiol by reaction of bis-aminoethyldisulfide and bis-4-aminophenyl-disulfide with thionyl chloride under a variety of conditions has been studied. The reaction of N-2-chloroethyl-benzenesulfinamide and N-3-chloropropyl-benzenesulfinamide with reagents which usually convert halides to thiols gave no N-mercaptoalkyl-benzenesulfinamide. Various methods for the preparation of hydrazinothiols have been studied. A promising sequence is HSCH2CO2CH3 yields HSCH2CONCH3NH2 yields HSCH2CH2NCH3NH2. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE