Accession Number:

AD0256734

Title:

STUDIES ON METABOLISM AND MECHANISMS OF DESTRUCTION OF THE FORMED ELEMENTS OF THE BLOOD

Descriptive Note:

Corporate Author:

ROCHE PRODUCTS LTD WELWYN (ENGLAND)

Personal Author(s):

Report Date:

1961-05-31

Pagination or Media Count:

1.0

Abstract:

Dialyzable plasma phosphorous is not incorporated into erythrocyte lipids. Plasma phospholipids emulsified in aqueous media by ultrasonic vibration are incorporated into the erythrocyte lipids at the same rate that they are incorporated from whole plasma. Influx of lipid phosphorous from plasma is greatly increased over normal when erythrocytes stored in ACD solution at 4 C. for less than 4 wk are then incubated at 37 C. Erythrocytes from patients with Hereditary Spherocytosis show rapid alterations in the membrane lipids upon in vitro incubation. Plasma and er throcytes from patients with Acanthocytosis show marked reductions in their content of lecithin and linoleic acid. In vivo removal mechanisms, in addition to the metabolic defect, are essential in producing hemolytic anemia in subjects with glucose-6-PO4 dehydrogenase deficiency. Erythrocyte calcium may exist in an easily exchangeable pool 30 and a slowly exchangeable pool 70. Single intravenous administration of EDTA 200 mgkg. produces vacuolar changes of enal proximal tubule epithelium in the dog. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE