RESEARCH ON NEUROPATHOLOGICAL EFFECTS OF MILITARY CHEMICALS
Semi-Annual rept., 1 Oct 1960-31 Mar 1961
MARYLAND UNIV COLLEGE PARK
Pagination or Media Count:
The main purpose of the work is to re-examine which concentration of CO in the air can be tolerated by healthy individuals for a prolonged period of time without producing permanent organic damage. The first step consisted of single exposures of various length to different concentrations of CO under the best possible control of physiological reactions in order to gain a better insight into the mechanism of the lesions. The second step is planned to consist of long term exposures of groups of animals to CO concentrations critical for the occurrence of permanent damage and below such level. The exposures are planned to be of continuous as well as interrupted type. Studies were made on single exposures to CO of various concentrations and of various durations. For the matter of comparison, some animals were exposed to oxygen deficiency equivalent to certain levels of CO hypoxia. Information for each experiment as to the concentration of CO or O2, the duration of exposure, the maximum CO saturation in the blood during the experiment, the survival time and the absence or presence of pathologic tissue alterations is tabulated.