NEUROLOGICAL MECHANISMS IN EPILEPSY AND BEHAVIOR
Annual progress rept. 15 Apr 1960-15 Apr 1961
YALE UNIV NEW HAVEN CT
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Methods for remote controlled stimulation of the brain described in the literature are unreliable, mainly because intensity of stimulation changes if the orientation of the receiving antenna is modified by animal movements. Also, the monitoring of stimulation is often difficult. These problems, as well as others, seem to be solved by a new method for radio-controlled electrical stimulation of the brain. A study was begun of cerebral-gastrointestinal correlations. In a group of seven monkeys, cannulas were permanently implanted in the stomach, and multilead electrodes permanently implanted in the brain. Some of the control studies, as well as the reactions after histamine injection seemed to indicate that gastrointestinal functions in the Macaca Mulatta are similar to those in human beings, and different from those in other experimental animals, such as cats and dogs. The study of aminophenylpyridone was continued with a derivative named carbomethoxy-aminophenylpyridone, which produces int resting behavioral disassociation with simultaneous drowsiness and increased aggressiveness. Considerable modification of the electrical activity of the brain was recorded over a wide area of the cerebral cortex, while the activity was only slightly modified in some of the limbic structures.
- Medicine and Medical Research