THERMAL INJURY OF THE SKIN
Annual rept. 1 May 1960-1 May 1961
ILLINOIS UNIV AT THE MEDICAL CENTER CHICAGO COLL OF MEDICINE
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Studies were conducted to demonstrate that following tissue injury thermal, traumatic, radiation, chemical there develops degradation products of tissue breakdown which can be toxic and lethal to the host and that these toxins at as foreign bodies in the host and stimulate the production of autoantibodies. A toxin has been isolated directly from diffusates of burned skin of rats in vivo circumventing the circulation. This toxin is fatal to mice and rats in acute or chronic experiments. Injection of this toxin plus Freunds adjuvant into rabbits produces precipitins to the toxin and hemoagglutinins and hemolysins to red cells of acutely burned rats. In preliminary experiments in mice, this rat-toxin rabbit anti-sera, when incubated with or injected after rat toxin detoxifies appreciably the action of the toxin. Thus far it has been shown that the serum of burned human subjects is cytotoxic to HeLa cells, cytolytic to injured red cells, and that the sera of healed burned humans have an enhanced capacity to neutralize the cytotoxic effect on HeLa cells in vitro, and clinical evidence suggests a similar in vivo effect.
- Stress Physiology