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LIPIDS OF THE RAT LIVER MITOCHONDRIAL MEMBRANE: EFFECT OF X-IRRADIATION
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF
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Data show that irradiation does not cause a loss of any of the major classes of lipids from the mitochondrial membrane during the first 40 minutes following 1000 r whole-body X-irradiation. Because X-irradiation is known to destroy unsaturated fatty acids from the membrane phospholipids. Rather, irradiation caused an increase in the amounts of the unsaturated fatty acids, linoleic and arachidonic acid, in the phosphatidyl choline fraction of the membrane. It is clear that whatever the mechanism is, whereby liver mitochondria are altered during an early period following irradiation, it does not involve major destruction of lipids in the mitochondrial membrane. Author
APPROVED FOR PUBLIC RELEASE