Accession Number:

AD0255138

Title:

SEROLOGICAL SURVEY FOR HERPES ANTIBODIES AMONG A POPULATION IN A LIMITED AREA OF TOKYO AND VICINITY AND ATTEMPTS TO GROW HERPES B VIRUS AND RICKETTSIA ORIENTALIS IN THE ONE-DAY OLD EGG

Descriptive Note:

Corporate Author:

NATIONAL INST OF HEALTH TOKYO (JAPAN)

Personal Author(s):

Report Date:

1961-03-20

Pagination or Media Count:

1.0

Abstract:

Nineteen more serum samples obtained from outpatients of a hospital and 23 serum samples taken from adult personnel were subjected to nasotracheal NT and complement-fixation test CFT. The data substantiated our previous conclusion that during the first year since birth only a minor or doubtful level of antibody remained by NT but mostly negative titers were obtained by CFT, and from the age of 3 years on both the NT AND CFT antibodies showed significant rises up to the age of 5 yr, after which about 50 of population revealed the presence of antibodies. Among adults, this ratio was about 60. In order to know what changes have occurred recently in herpes antibody distribution among the Tokyo population, a retrospective study is now going on using serum samples taken and frozen during the past two years. When a freshly isolated herpes B virus was inoculated in 1-day eggs, a luxuriant growth of virus was seen, the highest concentration being found in the CAM-yolk sac portion. The virus growth was better than that occurring after inoculation of 12-day eggs. The virus at the 2nd to 3rd egg passages showed a high 1-day-egg-cidal action so that it could be titrated by the 1-day egg LD titration. Two strains of Rickettsia orientalis, Kato and Karp, were tested for growth in 1-day eggs. Quite different from the cases of virus infection of eggs, the 1-day egg was far less susceptible to the rickettsial infection than older eggs. Serial 1-day egg passages resulted in the loss of rickettsia after 2 to 4 passages. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE