Accession Number:
AD0163767
Title:
Meningococcal Polysaccharide Vaccines.
Descriptive Note:
Patent,
Corporate Author:
OFFICE OF THE SECRETARY OF THE ARMY WASHINGTON D C
Personal Author(s):
Report Date:
1972-01-18
Pagination or Media Count:
8.0
Abstract:
The patent is a process for preparing and isolating antigenic group-specific polysaccharides of serologic group A and group C memingococci used as vaccines. The process employs a cationic substance, such as hexadecyl trimethylammonium bromide, to precipitate the polysaccharide from the whole culture. The antigenic polysaccharides isolated by this process are of high molecular weight molecular weight 60,000-5,000,000. The main constituent of the antigenic group A polysaccharide is N-acetyl, O-acetyl mannosamine phosphate and the main constituent of the antigenic group C polysaccharide is N-acetyl, O-acetyl neuraminic acid. The two antigenic polysaccharides are useful for producing immunity against meningococcal meningitis in humans.
Descriptors:
Subject Categories:
- Pharmacology