Accession Number:

AD0163767

Title:

Meningococcal Polysaccharide Vaccines.

Descriptive Note:

Patent,

Corporate Author:

OFFICE OF THE SECRETARY OF THE ARMY WASHINGTON D C

Personal Author(s):

Report Date:

1972-01-18

Pagination or Media Count:

8.0

Abstract:

The patent is a process for preparing and isolating antigenic group-specific polysaccharides of serologic group A and group C memingococci used as vaccines. The process employs a cationic substance, such as hexadecyl trimethylammonium bromide, to precipitate the polysaccharide from the whole culture. The antigenic polysaccharides isolated by this process are of high molecular weight molecular weight 60,000-5,000,000. The main constituent of the antigenic group A polysaccharide is N-acetyl, O-acetyl mannosamine phosphate and the main constituent of the antigenic group C polysaccharide is N-acetyl, O-acetyl neuraminic acid. The two antigenic polysaccharides are useful for producing immunity against meningococcal meningitis in humans.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE