Accession Number : ADP001969


Title :   Immunosuppression Following Exposure to Exogenous Estrogens


Corporate Author : NATIONAL INST OF ENVIRONMENTAL HEALTH SCIENCES RESEARCH TRIANGLE PARK NC


Personal Author(s) : Luster, Michael I ; Hayes, Howard T ; Boorman, Gary A ; Pung, Oscar ; Dean, Jack H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/p001969.pdf


Report Date : Aug 1983


Pagination or Media Count : 12


Abstract : Exposure to pharmacological dosages of estrogens, including 17 beta- estradiol and DES, selectively affects immune responses. This immunologic profile is consistent with myelotoxicity, suppression of cell mediated immunity (CMI), and induction of inflammatory macrophages. Modulation of several of these functions is mediated through the thymus, since thymectomy abolishes estrogen- induced macrophage activation, inhibition of CFU-kinetics and increased susceptibility to Listeria infection, but does not inhibit depression of CMI or bone marrow cellularity. These effects can also be dissociated chemically as zearalanol, an estrogenic mycotoxin, influences macrophage activity and CFU kinetics without affecting CMI. This may be due to structural differences since zearalanol is similar to DES and estradiol in the A-ring region but not D-ring region of the molecule. Underlying this explanation is the demonstration that many of these effects are apparently mediated through estrogen receptors, as indicated indirectly by inhibition with estrogen antagonist and the demonstration of estrogen receptors in thymus and bone marrow cell cytosol preparations.


Descriptors :   *IMMUNOSUPPRESSION , *ESTROGENS , SYMPOSIA , TOXICITY , VULNERABILITY , DOSAGE , EXPOSURE(PHYSIOLOGY) , PHARMACOKINETICS , MICE , IMMUNOLOGY , INFECTIOUS DISEASES , INFLAMMATION , LYMPHOCYTES , BONE MARROW , COLONIES(BIOLOGY) , PHYTOTOXINS , TOXICOLOGY , LISTERIA , THYMUS


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE