Accession Number : ADB370363


Title :   Chemical Warfare Agent Operational Exposure Hazard Assessment Research: FY07 Report and Analysis


Descriptive Note : Final rept. Oct 2006-Sep 2007


Corporate Author : ARMY EDGEWOOD CHEMICAL BIOLOGICAL CENTER APG MD RESEARCH AND TECHNOLOGY DIR


Personal Author(s) : Reutter-Christry, Sharon ; Sommerville, Douglas R ; Jakubowski, Edward M ; Whalley, Christopher E ; Benton, Bernard J ; Hulet, Stanley W ; Dabisch, Paul A ; Evans, Ronald A ; McGuire, Jeffrey M ; Byers, Christopher E ; Manthei, James H ; Moretz, Ruth W ; Forster, Jeffry S ; Gaviola, Bernadita I ; Burnett, David C ; Muse, William T ; Matson, Kathy L ; Crouse, Charles L ; Mioduszewski, Robert J ; Thomson, Sandra A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b370363.pdf


Report Date : Jul 2010


Pagination or Media Count : 152


Abstract : Contact hazard, defined as the toxicological hazard arising from any potentially contaminated surface that is capable of transferring toxic quantities of chemical agent to the skin, is studied in a series of animal models. Physiological parameters were developed in the guinea pig model to compare toxicity and kinetic data for the nerve agents, VX, GB, or GF, and to determine lethal percutaneous (PC) levels of VX. Calibration of Physiologically-based pharmacokinetic biomarkers (dose-metrics) were determined in a miniature swine model, achieving very sensitive detection levels for GB/GF products in plasma and tissue partition coefficients for VX. Rabbit studies extended the dose-response data for PC exposure to VX. The comparison of neat and dilute VX doses indicates that for a PC exposure, the VX/IPA (VX in isopropyl alcohol) solution was two times more potent than the neat agent for the ED(50)mild and ED(50)(moderate).


Descriptors :   *CHEMICAL WARFARE AGENTS , CONTAMINATION , DETECTION , EXPOSURE(PHYSIOLOGY) , HAZARDS , RESPONSE(BIOLOGY) , SENSITIVITY , SKIN(ANATOMY) , VX AGENT


Subject Categories : Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE