Accession Number : ADB281571


Title :   Contribution of the Receptor/Ligand Interaction Between CD44 and Osteopontin to Formation of Breast Cancer Metastases


Descriptive Note : Annual rept. 1 Jul 2000-30 Jun 2001


Corporate Author : NEW ENGLAND MEDICAL CENTER HOSPITAL BOSTON MA


Personal Author(s) : Weber, George F


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b281571.pdf


Report Date : Jul 2001


Pagination or Media Count : 112


Abstract : Splice variants of the homing receptor CD44 may mediate metastasis formation by various tumors through interaction with the cytokine osteopontin, which mediates cell attachment or migration. We have identified the mechanism of cell motility as a two step process involving both major osteopontin receptors. We have further characterized this process by studying signal transduction associated with ligation of each receptor. Because osteopontin structure can be extensively modified on the posttranslational and posttranscriptional levels with substantial consequences for its function we are now analyzing the osteopontin transcripts from various cancer cells for alterations.


Descriptors :   *CELLS(BIOLOGY) , *RECEPTOR SITES(PHYSIOLOGY) , *SPLICES , *METASTASIS , *BREAST CANCER , INTERACTIONS , SIGNALS , LIGANDS , TRANSDUCERS , ATTACHMENT , SENSE ORGANS , CYTOKINES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE