Accession Number : ADB274474


Title :   Nuclear Tubulin: A Novel Target for Breast Cancer Chemotherapy


Descriptive Note : Final rept. 1 May 1998-30 Apr 2001


Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT SANANTONIO


Personal Author(s) : Luduena, Richard F


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b274474.pdf


Report Date : May 2001


Pagination or Media Count : 274


Abstract : Our research is based on our observation that the beta x isotype of tubulin is found in the nuclei of cultured breast cancer cells. Our goals are to learn the function of beta x and to design a novel anti-tumor drug that will target beta x. We have found that the process by which beta x enters the nucleus is specific for that isotype and that nuclear beta x, while very rare in normal cells, is a characteristic of 80% of all tumors, including 100% of breast tumors. We have found that successful anti-tumor drugs (taxol, vinblastine) expel beta x from the nuclei of tumor cells. We have also found that the beta x isotype may be involved in making tumor cells resistant to oxidation while the beta x isotype can interact with actin filaments in a process regulated by the beta x isotype. We also synthesized a peptidyl- colchicine derivative designed to target the nucleus. Our results indicate that nuclear beta x may be very important in the diagnosis, prognosis, biology and treatment of breast cancer.


Descriptors :   *CHEMOTHERAPY , *BREAST CANCER , NEOPLASMS , DRUGS , CELLS(BIOLOGY) , NUCLEI(BIOLOGY) , COLCHICINE


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE