Accession Number : ADB262441


Title :   Gene Discovery in Prostate Cancer: Functional Identification and Isolation of PAC-1, a Novel Tumor Suppressor Gene Within Chromosome 10p


Descriptive Note : Annual rept. 1 Sep 1998-31 Aug 1999


Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX


Personal Author(s) : Killary, Ann M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b262441.pdf


Report Date : Sep 1999


Pagination or Media Count : 57


Abstract : We have previously identified a novel genetic locus PAC-1 (Prostatic Adenocarcinoma-1) involved in tumor suppression of human prostate carcinoma. Introduction of human chromosome 10p into prostate adenocarcinoma cells resulted in tumor suppression and a restoration of the cell death pathway in vivo. The specific aims of this award involve both an expression based and positional cloning based strategy to identify PAC-1. As a first step in this strategy, we identified a region of homozygous deletion within a prostate cell line that falls within a region we identified as having tumor suppressor functional activity in vivo. Thus, we report the narrowing of the region containing PAC-1 to a homozygous deletion region. The next step in the strategy will be to clone the homozygous deletion region and identify this important tumor suppressor gene for prostate cancer.


Descriptors :   *IN VIVO ANALYSIS , *PROSTATE GLAND , *PROSTATE CANCER , HUMANS , NEOPLASMS , IDENTIFICATION , GENES , DEATH , CELLS(BIOLOGY) , SUPPRESSION , SUPPRESSORS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE