Accession Number : ADB259953


Title :   Elucidating the Role of cAbl and the Abi-Family of cAbl Target Proteins in Cancer Development and Progression


Descriptive Note : Annual summary rept. 1 Jul 1998-30 Jun 1999


Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC


Personal Author(s) : Courtney, Kevin D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b259953.pdf


Report Date : Jul 1999


Pagination or Media Count : 27


Abstract : Abl-interactor (Abi) proteins bind and are phosphorylated by the non-receptor tyrosine kinases Abl and Arg. Two Abi family genes, Abi-1 and Abi-2, have been identified. Abi proteins demonstrate properties consistent with a potential tumor suppressor function. We investigated the role of Abi- 1 and Abi-2 proteins and their interactions with c-Abl and c-Abl-derived oncogenes in normal development and tumorigenesis. Abi-1 and Abi-2 exhibit both unique and overlapping temporal-spatial patterns of expression during embryonic and post-natal mouse development. Abi-2 is enriched in regions of the central and peripheral nervous systems (CNS and PNS) pre- and post-natally. Abi-1 is also enriched in regions of the post-natal brain, but is not enriched in the pre-natal CNS and is absent from examined PNS structures. Abi proteins undergo changes in phosphorylation during development.


Descriptors :   *PROTEINS , *BREAST CANCER , NEOPLASMS , NERVE CELLS , GENES , FIBROBLASTS , CELLS(BIOLOGY) , TYROSINE , PHOSPHORYLATION , PHOSPHORUS TRANSFERASES , ONCOGENIC VIRUSES


Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE