Accession Number : ADB257446


Title :   Genetic and Dynamic Analyses of Murine Peak Bone Density


Descriptive Note : Annual rept. 27 Sep 1998-26 Sep 1999


Corporate Author : JACKSON LAB BAR HARBOR ME


Personal Author(s) : Beamer, Wesley G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b257446.pdf


Report Date : Oct 1999


Pagination or Media Count : 33


Abstract : During our third year, the major effort has continued with genetic analyses of normal bone mineral density using inbred strains of mice differing by 35-50% in volumetric BMD. All (C57BUL/6x C3H/He)F2 and (C57BL/6x CAST/Ei)F2 mice have been phenotyped for femoral vBMD and (36 x C3H)F2 have been phenotyped for vertebral vBMD. Both F2 populations have been genotyped for the 10% of mice with the highest and 10% with the lowest bone densities. Genome-wide analyses of (B6x CAST)F2 mice revealed strong vBMD loci on 4 Chromosomes (Chrs 1, 5, 13, 15) and suggestive vBMD loci on 4 additional Chrs (3,4, 10, & 14). Genome wide analyses of (B6x C3H)F2 mice revealed strong vBMD loci on 5 Chrs (1,4, 11, 13, & 18) and suggestive vBMD 1oci on 3 additional Chrs (6, 14, & 16). Congenic strains carrying Chr regions from CAST (1,' 3, 5, 13, & 14) or regions from C3H (1, 4, 6, 13, &18) have significantly altered femoral vBMD as a consequence of the donated Chr segment. Preliminary mapping data for (B6x C3H)F2 vertebrae reveal 4 vBMD loci shared with femurs (1,4, 14, & 18) and 2 unique loci (Chr 7 & 9). Lastly, a new DEXA instrument for mice, the PIXImus, has been validated for body composition, and demonstrated capable of detecting the major loci for BMD shared with the femoral bone site.


Descriptors :   *DENSITY , *BONES , *OSTEOPOROSIS , PEAK VALUES , HORMONES , GENETICS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE