Accession Number : ADB255697


Title :   Screening for Ataxia-Telangiectasia Mutations in a Population-Based Sample of Women with Early-Onset Breast Cancer


Descriptive Note : Final rept. 19 Aug 1996-18 Aug 1999


Corporate Author : VIRGINIA MASON RESEARCH CENTER SEATTLE WA


Personal Author(s) : Teraoka, Sharon


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b255697.pdf


Report Date : Sep 1999


Pagination or Media Count : 80


Abstract : We are assessing whether a mutated allele of the Ataxia-telangiectasia gene, ATM, is a genetic risk factor for breast cancer, by screening for ATM mutations in patients with early- onset breast cancer. These patients were derived from a large population-based, case-control study of primary breast cancer in Western Washington. We are screening genomic DNAs by SSCP (single strand conformation polymorphism) analysis of the 62 coding exons amplified by multiplex PCR. In 142 breast cancer cases with early-onset or family history, we have found no truncation or deletion mutations in the ATM gene. family history of breast cancer.


Descriptors :   *MUTATIONS , *BREAST CANCER , HISTORY , GENES , GENETICS , AMINO ACIDS , FAMILIES(HUMAN) , POLYMORPHISM , NUCLEOTIDES


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE