Accession Number : ADB255338


Title :   Effects of Diet High in Palmitoleic Acid on Serum Lipid Levels and Metabolism


Descriptive Note : Final rept. 15 Mar 1997-14 Jun 2000


Corporate Author : HAWAII UNIV AT MANOA HONOLULU


Personal Author(s) : Curb, Jesse D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b255338.pdf


Report Date : Jul 2000


Pagination or Media Count : 69


Abstract : A randomized crossover feeding study with a macadamia nut and oil based high monounsaturated fat diet (HIMUFA) and a typical American diet high in saturated fat (HISAT) was conducted on 27 healthy men and women aged 20 to 52. Fatty acid profiles were HIMUFA: 22% MUFA, 9% SEA; HISAT: 11% MUFA, 20% SFA. Each diet was consumed for 8 weeks with a 2-month wash-out. Fasting plasma lipids and lipoprotein subclasses by using NMR or chemical analysis were measured on week 5 and the last two consecutive days of week 8 in each diet period. Isoenergenic substitution with 11% Kcal MUFA for SEA significantly reduced plasma total cholesterol, LDL, HDL, VLDL and TG (in NMR). A small but significant reduction in both LDL and HDL particle size in the HIMUFA diet compared to the HISAT diet. These were due to the reductions in larger particles- L3, and HDL2 (H5, H4). LDL particle concentrations in parallel with LDL levels were significantly reduced in the HIMUFA diet. The cholesterol lowering effects in total cholesterol and LDL of the HIMUFA diet are very prominent. Macadamia nut based MUFA can be a good alternative for SEA in the diet to lower CHD risks. Further investigations are warranted to evaluate the long-term beneficial effects of HIMUFA on CVD risk.


Descriptors :   *LIPIDS , *METABOLISM , *CHOLESTEROL , SATURATION , FATS , BLOOD SERUM , DIET , LIPOPROTEINS , CHEMICAL ANALYSIS , FOOD DEPRIVATION , FATTY ACIDS , SERUM TRIGLYCERIDES


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE