Accession Number : ADB233503


Title :   Megakaryocytopoiesis in Stem Cell Transplantation


Descriptive Note : Annual rept. 16 Sep 96-15 Sep 97


Corporate Author : NORTHWESTERN UNIV EVANSTON IL


Personal Author(s) : Cohen, Isaac


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b233503.pdf


Report Date : Oct 1997


Pagination or Media Count : 26


Abstract : The overall objective of this research proposal is to investigate several laboratory protocols to improve megakaryocyte production for future clinical use of an autologous megakaryocyte-rich product. Conditioned medium from bone marrow stromal cultures enhances the thrombopoietin stimulated megakaryocyte production by at least 3-fold by a still unknown mechanism. We were able to rule out any role of stromal concentrations of thrombopoietin, interleukins 3 and 6, stem cell factor and heparan sulfates on this enhancing effect.


Descriptors :   *TRANSPLANTATION , *BREAST CANCER , HEMATOPOIETIC SYSTEM , BONE MARROW , SYNERGISM , BLOOD DISEASES , CHEMOTHERAPY , COAGULATION , BLOOD PLATELETS , THROMBOCYTOPENIA , BLOOD CHEMISTRY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE