Accession Number : ADB218568


Title :   Oral Vaccination Against Anthrax Using a Transgenic Plant Expressing Protective Antigen.


Descriptive Note : Final rept. 15 Aug 1995-14 Aug 1996


Corporate Author : CROPTECH DEVELOPMENT CORP BLACKSBURG VA


Personal Author(s) : Oishi, Karen K


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b218568.pdf


Report Date : Sep 1996


Pagination or Media Count : 34


Abstract : The goal of this proposal is to develop transgenic plants for the production of oral food-based delivery of new recombinant vaccines against the plague and anthrax. The major goal of the Phase 1 contract was to generate transgenic plant material expressing three different antigens: the Bacillus anthracis protective antigen (PA), the Yersinia pestis V antigen modified to contain a His6 epitope to facilitate affinity purification (His-Tag V), and the Y pestis F1 antigen, with potential for anthrax and bubonic plague vaccines, respectively. We will briefly introduce the disease and the rationale for selection of targeted antigens.


Descriptors :   *ANTHRAX , *ANTIGENS , *ORAL DOSAGE , *VACCINES , INFECTIOUS DISEASES , IMMUNIZATION , PLAGUES , BACILLUS ANTHRACIS


Subject Categories : Biochemistry
      Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE