Accession Number : ADB212163


Title :   Enterotoxin Vaccine Delivery System With Bioadherence. Phase 1.


Descriptive Note : Final rept. 25 Apr 95-5 Dec 95,


Corporate Author : CDS INC KETTERING OH


Personal Author(s) : Dues, Ronald P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b212163.pdf


Report Date : 05 Dec 1995


Pagination or Media Count : 35


Abstract : The primary of this Phase I program was to provide a stable peroral controlled delivery system for a vaccine which was designed to release its contents in the intestinal tract with or without an immunoadjuvant. A single administration of the vaccine must release at a rate sufficient for inoculation of the host immune system for up to six months. To insure sustained release in an environment as dynamic as the intestinal mucosa, adherence to the host tissue for several days is essential. Adhesion of this magnitude will require a delivery system configured with a bioadhesive polymer.


Descriptors :   *ADHESION , *ENTEROTOXINS , *VACCINES , DELIVERY , POLYMERS , RELEASE , BIODEGRADATION , IMMUNITY , MEDICAL PERSONNEL , ADHESIVES , ANTIGENS , INTESTINES , MUCOUS MEMBRANES


Subject Categories : Biochemistry
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE