Accession Number : ADB205250

Title :   Production of Polyclonal Antibodies in Rabbits

Descriptive Note : Final rept. 1 Mar 1993-31 Aug 1995

Corporate Author : BIOTEK INC WOBURN MA

Personal Author(s) : Nuwayser, Elis S

Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b205250.pdf

Report Date : Oct 1995

Pagination or Media Count : 103

Abstract : The project was directed to the Medical Chemical Defense Research Program. Under the broad mission of providing medical countermeasures to chemical warfare agents, the work was relevant to develop the use of exogenous cholinesterase enzymes as a pretreatment to protect against organophosphorous chemical agents. The threat of deadly exposure to chemical agents is still significant for American military personnel and the American public. The recent use of sarin by Japanese extremists in subway sta- tions in Japan is witness to that. Amongst the most lethal chemical agents are organophosphorous (OP) compounds such as soman, sarin, and tabun. Poisoning from these agents can lead to rapid and severe dysfunction and even death from respiratory failure within five minutes (Gilman, et al., 1990).

Descriptors :   *CHEMICAL WARFARE AGENTS , *CHOLINESTERASE , *COUNTERMEASURES , *MEDICINE , *MILITARY MEDICINE , *MONOCLONAL ANTIBODIES , DEATH , DYSFUNCTION , ENZYMES , EXPOSURE(GENERAL) , FAILURE , GA AGENT , GB AGENT , GD AGENT , JAPAN , LETHAL AGENTS , MILITARY PERSONNEL , MISSIONS , ORGANIC PHOSPHORUS COMPOUNDS , ORGANOPHOSPHATES , POISONING , RABBITS , RESPIRATORY SYSTEM

Subject Categories : Medicine and Medical Research
      Biochemistry
      Chemical, Biological and Radiological Warfare

Distribution Statement : APPROVED FOR PUBLIC RELEASE