Accession Number : ADB160611


Title :   Research in Drug Development against Viral Diseases of Military Importance (Biological Testing). Volume 1


Descriptive Note : Final rept. 15 Nov 1985-31 Jan 1991


Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL


Personal Author(s) : Shannon, W M ; Arnett, G ; Brazier, A D ; Hollingshead, M G ; Kirsi, J J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/b160611.pdf


Report Date : 01 Mar 1991


Pagination or Media Count : 417


Abstract : The purpose of this program is to evaluate the efficacy of candidate antiviral compounds against a spectrum of viruses of military importance. This program involves (a) primary testing of chemical compounds and natural products for antiviral efficacy in vitro using standard CPE-inhibition assays, (b) primary testing of compounds for antiviral efficacy in vivo in animal model systems, and (c) secondary evaluation of the active candidate antiviral compounds. The target viruses for in vitro testing are Vaccinia Virus (VV), Adenovirus (AD2), Vesicular Stomatitis Virus (VSV), Punta Toro Virus (PT), Sandfly Fever Virus (SF), Yellow Fever Virus (YF), Venezuelan Equine Encephalomyelitis Virus (VE), Japanese Encephalitis Virus and Vaccinia Virus infections of mice. Approximately 10,000 compounds have been received for in vitro evaluation and over 66,000 assays have been performed on this contract. Compounds have been identified in nearly all virus systems that have confirmed antiviral activity equal or exceeding that of the various positive control compounds (Ribavirin, Selenazofurin, Carbocyclic-3-deaza-adenosine, Adenosine dialdehyde, Ara-A, ddC and AZT). Many of these compounds represent potent and selective new antiviral agents.


Descriptors :   *VIRUS DISEASES , ADENOSINE , ADENOVIRUSES , ANIMALS , ANTIVIRAL AGENTS , ASSAYING , BIOLOGY , CHEMICAL COMPOUNDS , CONTRACTS , CONTROL , DRUGS , EFFICIENCY , IN VITRO ANALYSIS , IN VIVO ANALYSIS , JAPANESE ENCEPHALITIS VIRUSES , MICE , MODELS , NATURAL RESOURCES , POTENCY , SANDFLY FEVER VIRUS INFECTION , SECONDARY , SPECTRA , TARGETS , TEST AND EVALUATION , VACCINIA VIRUS , VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS , VESICULAR STOMATITIS , VIRUSES , VOLUME , YELLOW FEVER VIRUS


Subject Categories : Medicine and Medical Research
      Microbiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE