Accession Number : ADA640753


Title :   Diseno de una matriz de soporte compuesta de colageno de piel de tiburon-aloe para ingenier a tisular (Design of Shark Skin Collagen-Aloe Composite Scaffold for Tissue Engineering)


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Shanmuganathan, S ; Shanmugasundaram, N ; Adhirajan, N ; Ramyaa Lakshmi, T S ; Babu, M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a640753.pdf


Report Date : Jan 2008


Pagination or Media Count : 21


Abstract : Collagen has proven to be a novel biomaterial used for drug delivery, wound cover dressings or as a substrate for tissue engineering with unique biocompatibility and biodegradable properties. Bovine and porcine Type I collagen provide a readily available source of scaffold material for various biomedical applications. However these sources have some potential risk of infectious diseases such as bovine spongiform encephalopathy or transmissible spongiform encephalopathy. Hence there is demand for an alternative Type I collagen from various other sources. The present study utilizes the aquatic animals particularly the shark species in which collagen Type I is a major protein in the skin and the structure has similarity to that of mammalian species. An attempt was made to use shark skin collagen as scaffold with the extract of aloe to improve the stability. These scaffolds were characterized for various physicochemical properties and biocompatibility assessment to support the growth of human dermal fibroblasts in vitro. The incorporation of aloe extract highly influenced the morphology and physicochemical properties of the scaffold. It was observed in vitro that the fibroblasts retained the spindle shape, organized orientation when cultured over collagen scaffold. Thus the developed collagen scaffold at 10: 1 ratio of shark skin collagen and aloe extract respectively served as a biocompatible material with appreciable tensile strength. The above investigation suggests that the developed shark skin collagen scaffold could be an effective alternative for the mammalian collagen for tissue engineering and various wound healing applications.


Descriptors :   *COLLAGEN , *PHYSICOCHEMICAL PROPERTIES , AMINO ACIDS , CROSSLINKING(CHEMISTRY) , PEPTIDES , SHARKS , SPANISH LANGUAGE


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE