Accession Number : ADA634964


Title :   Effects of Naloxone on Stress and Performance


Descriptive Note : Doctoral thesis


Corporate Author : UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD


Personal Author(s) : Davidson, Laura M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a634964.pdf


Report Date : 10 Nov 1987


Pagination or Media Count : 157


Abstract : Studies suggest that exposure to unpredictable stressors results in performance deficits following stressor termination. Stressor exposure may also be accompanied by activation of the endogenous opioid system which may play a role in affective responding to stressors. It is possible that opioid effects are related to these aftereffects of stress because opioids cause effects that are similar to aftereffects. The major hypothesis of this study was that naloxone, an opioid antagonist, would ameliorate aftereffects due to exposure to uncontrollable noise. It was also hypothesized that naloxone would increase the reported aversiveness of the stressor, but would have no effect on simple performance during stressor exposure.


Descriptors :   *PHARMACOLOGICAL ANTAGONISTS , *STRESS(PHYSIOLOGY) , ACTIVATION , EXPOSURE(GENERAL) , NOISE , OPIUM ALKALOIDS , PERFORMANCE(HUMAN)


Subject Categories : Medicine and Medical Research
      Stress Physiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE