Accession Number : ADA634925


Title :   Modulation of Polymorphonuclear Neutrophil Response to N-formyl-l-methionyl-l-leucyl-l-phenylalanine


Descriptive Note : Doctoral thesis


Corporate Author : UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD


Personal Author(s) : Linnekin, Diana M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a634925.pdf


Report Date : 10 Nov 1988


Pagination or Media Count : 215


Abstract : N-formyl-1-methionyl-1-leucyl-1-phenylalanine (FMLP) is a potent stimulant of migration and superoxide production by polymorphonuclear neutrophils (PMNs) from many species. Dog and rhesus monkey PMNs are poorly responsive to FMLP and believed not to express the formylpeptide receptor. The objectives of these studies were to determine if PMNs from dogs and rhesus monkeys could be modified with certain agents to migrate or generate an oxidative burst in response to FMLP.


Descriptors :   *PHENYLALANINE , *POLYMORPHONUCLEAR NEUTROPHILS , CHEMICAL ANALOGS , DOGS , ESCHERICHIA COLI , MODULATION , PEPTIDES , RECEPTOR SITES(PHYSIOLOGY) , RESPONSE(BIOLOGY) , RHESUS MONKEYS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Organic Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE