Accession Number : ADA632486


Title :   Fas Protects Breast Cancer Stem Cells from Death


Descriptive Note : Annual rept. 15 Sep 2014-14 Sep 2015


Corporate Author : NORTHWESTERN UNIV EVANSTON IL


Personal Author(s) : Ceppi, Paolo


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a632486.pdf


Report Date : Oct 2015


Pagination or Media Count : 11


Abstract : During the awarded period my investigations on Fas (also called CD95) signaling in breast cancer and in breast cancer stem cells (BCSCs) led me to identify a novel life-protective role for Fas. Briefly, I found that the non-BCSCs component of a breast tumor is more sensitive to Fas-mediated apoptosis, while the BCSCs part is more sensitive to the death induced by the elimination of CD95 (a phenomenon we have recently described and named DICE). This was found in different breast cancer cells lines and further investigations will provide the basis for the identification of novel molecular targets for the treatment of breast cancer. I have in fact observed a significant enhancement of cancer cell death by simultaneously inducing apoptosis and DICE in breast cancer cells, with many potential therapeutic applications. I could also demonstrate the involvement of miRNA in the process. Moreover, I have developed a novel plasmid-based tool to isolate BCSCS by the activity of miRNAs. The results were published in conferences and scientific journals.


Descriptors :   *APOPTOSIS , *BREAST CANCER , *STEM CELLS , CLINICAL MEDICINE , DEATH , EPITHELIUM , GENE EXPRESSION , LIGANDS , MAMMARY GLANDS , NEOPLASMS , PATHOLOGY , PATIENTS , RESISTANCE(BIOLOGY) , RESPONSE(BIOLOGY) , RIBONUCLEIC ACIDS , THERAPY


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE