Accession Number : ADA631785


Title :   Serotonin as a Biomarker: Stress Resilience among Battlefield Airmen Trainees


Descriptive Note : Special rept. Jan 2015-May 2016


Corporate Author : SCHOOL OF AEROSPACE MEDICINE WRIGHT PATTERSON AFB OH AEROSPACE MEDICINE DEPT


Personal Author(s) : Wolf, Sky J ; Gallavan, Robert ; Kinchen, Mark J ; Shia, Regina


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a631785.pdf


Report Date : 21 May 2016


Pagination or Media Count : 13


Abstract : Epidemiologic data have shown that neuropeptide Y and dehydroepiandrosterone-sulfate have been found to predict successful performance under stress. Serotonin receptors and the serotonin transporter have been extensively studied for their efficacy in treating mental and physical disorders. In the present study, we sought to determine whether serotonin levels measured during Battlefield Airmen training were associated with stress resilience. We measured serotonin in blood samples from 21 Battlefield Airmen trainees prior to and during training for a total of six blood draws. Participants were divided into three groups: graduates, failures, and self-initiated eliminations. Failures included those who failed medically and those who failed performance. We analyzed the data using discriminant analysis. Of the 21 subjects in the analysis, all males with mean age 25 years (range, 18-35 years), 11 graduated (52.4%), 7 failed (33.3%), and 3 (14.3%) self-initiated elimination. Discriminant analysis showed that subjects with increased serotonin levels were more likely to self-initiate elimination. Although the sample was very limited, the findings demonstrate potential for using serotonin data to identify trainees who are likely to abandon training on their own. These data may improve the design of biomarker performance prediction models for stress, cognitive performance, and training ability relative to attrition rates, a U.S. Air Force School of Aerospace Medicine priority. It might also assist the design and development of real-time wearable sensor technology, an Air Force priority.


Descriptors :   *AIR FORCE PERSONNEL , *SEROTONIN , *TRAINEES , AGE DISTRIBUTION , BATTLEFIELDS , CARGO VEHICLES , COGNITION , DISCRIMINANT ANALYSIS , EPIDEMIOLOGY , MATHEMATICAL PREDICTION , MENTAL ABILITY , METABOLISM , NERVE CELLS , PEPTIDES , PERFORMANCE(HUMAN) , PHYSIOLOGICAL EFFECTS , RECEPTOR SITES(PHYSIOLOGY) , RESILIENCE , STRESS(PHYSIOLOGY)


Subject Categories : Biochemistry
      Medicine and Medical Research
      Stress Physiology
      Military Forces and Organizations


Distribution Statement : APPROVED FOR PUBLIC RELEASE