Accession Number : ADA629590


Title :   Early Initial Antibiotics and Debridement Independently Reduce Infection in an Open Fracture Model


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Penn-Barwell, J G ; Murray, C K ; Wenke, J C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a629590.pdf


Report Date : Jan 2012


Pagination or Media Count : 7


Abstract : Most animal studies indicate that early irrigation and debridement reduce infection after open fracture. Unfortunately, these studies often do not involve antibiotics. Clinical studies indicate that the timing of initial debridement does not affect the rate of infection but these studies are observational and fraught with confounding variables. The purpose of this study was to control these variables using an animal model incorporating systemic antibiotics and surgical treatment.


Descriptors :   *ANTIBIOTICS , *BONE FRACTURES , *INFECTIOUS DISEASES , *SURGERY , BACTERIA , CLINICAL MEDICINE , EXCISION , RADIOGRAPHY , RATS , REPRINTS , STAPHYLOCOCCUS AUREUS , TRAUMA , VARIABLES , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE