Accession Number : ADA629425


Title :   Contribution of Bacterial and Viral infections to Attributable Mortality in Patients with Severe Burns: An Autopsy Series


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : D'Avignon, Laurie C ; Hogan, Brian K ; Murray, Clinton K ; Loo, Florence L ; Hospenthal, Duane R ; Cancio, Leopoldo C ; Kim, Seung H ; Renz, Evan M ; Barillo, David ; Holcomb, John B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a629425.pdf


Report Date : Jan 2010


Pagination or Media Count : 8


Abstract : Bacterial infections are a common cause of mortality in burn patients and viral infections, notable herpes simplex virus (HSV) and cytomegalovirus (CMV) have also been associated with mortality. This study is a retrospective review of all autopsy reports from patients with severe thermal burns treated at the US Army Institute of Research (USAISR) burn unit over 12 years. The review focused on those patients with death attributed to a bacterial or viral cause by autopsy report. Of 3751 admissions, 228 patients died with 97 undergoing autopsy. Death was attributed to bacteria for 27 patients and to virus for 5 patients. Bacterial pathogens associated with mortality included Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. This association with mortality was independent of % total body surface area burn, % full thickness burn, inhalation injury and day of death post burn.


Descriptors :   *BURNS(INJURIES) , *INFECTIOUS DISEASES , AUTOPSY , BACTERIA , BACTERIAL DISEASES , COLONIES(BIOLOGY) , CYTOMEGALOVIRUS , DEMOGRAPHY , EMERGENCY MEDICINE , ESCHERICHIA COLI , EXPOSURE(PHYSIOLOGY) , HERPES SIMPLEX VIRUS , INHALATION , KLEBSIELLA PNEUMONIAE , MORTALITY RATE , PATHOGENIC MICROORGANISMS , PATIENTS , PSEUDOMONAS AERUGINOSA , REPRINTS , STAPHYLOCOCCUS AUREUS , SURVIVABILITY , VIRUS DISEASES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE