Accession Number : ADA627938


Title :   Sympathetic Responses to Central Hypovolemia: New Insights from Microneurographic Recordings


Descriptive Note : Journal article


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX


Personal Author(s) : Ryan, Kathy L ; Rickards, Caroline A ; Hinojosa-Laborde, Carmen ; Cooke, William H ; Convertino, Victor A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a627938.pdf


Report Date : 26 Apr 2012


Pagination or Media Count : 15


Abstract : Hemorrhage remains a major cause of mortality following traumatic injury in both military and civilian settings. Lower body negative pressure (LBNP) has been used as an experimental model to study the compensatory phase of hemorrhage in conscious humans, as it elicits central hypovolemia like that induced by hemorrhage. One physiological compensatory mechanism that changes during the course of central hypovolemia induced by both LBNP and hemorrhage is a baroreflex-mediated increase in muscle sympathetic nerve activity (MSNA), as assessed with microneurography. The purpose of this review is to describe recent results obtained using microneurography in our laboratory aswell as those of others that have revealed new insights into mechanisms underlying compensatory increases in MSNA during progressive reductions in central blood volume and how MSNA is altered at the point of hemodynamic decompensation. We will also review recent work that has compared direct MSNA recordings with non-invasive surrogates of MSNA to determine the appropriateness of using such surrogates in assessing the clinical status of hemorrhaging patients.


Descriptors :   *HEMORRHAGE , *NERVES , BLOOD VOLUME , CLINICAL MEDICINE , COMPENSATION , LABORATORIES , MORTALITY RATE , MUSCLES , PHYSIOLOGY , REDUCTION , RESPONSE , SYMPATHETIC NERVOUS SYSTEM


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE