Accession Number : ADA627069


Title :   Inhibiting Inosine Hydrolase and Alanine Racemase to Enhance the Germination of Bacillus anthracis Sterne Spores: Potential Spore Decontamination Strategies


Descriptive Note : Briefing charts


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Defez, Maryline ; Hunter, Melissa ; Welkos, Susan ; Cote, Christopher


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a627069.pdf


Report Date : 19 Jun 2015


Pagination or Media Count : 20


Abstract : Interest in context of novel decontamination strategies Increase of the germination rate induce: By inhibiting Air and lunH separately. By inhibiting the both concommitantly (iunH mutant spores positively affected by the block of Air). Better understanding and manipulating spore germination. Induction of the transition from highly resistant ungerminated spores to much more susceptible and less virulent germinated spores. Strengthens the early work published in 2013 and 2014 showing that spore germination rates are augmented potentially improving decontamination strategies.


Descriptors :   *ANTHRAX , *DECONTAMINATION , *GERMINATION , *SPORES , AUGMENTATION , ENZYMES , HYDROLASES , INOSINE , RATES , RESISTANCE , STRATEGY , TRANSITIONS , VIRULENCE


Subject Categories : Biology
      Medicine and Medical Research
      Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE