Accession Number : ADA626731


Title :   Infinite Coordination Polymer Nano- and Micro-Particles


Descriptive Note : Final rept. 15 Jun 2011-14 Mar 2015


Corporate Author : NORTHWESTERN UNIV EVANSTON IL


Personal Author(s) : Mirkin, Chad


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a626731.pdf


Report Date : 12 Jun 2015


Pagination or Media Count : 27


Abstract : Infinite coordination polymer (ICP) particles and metal-organic frameworks (MOFs) are attractive materials for a diverse array of applications, namely, catalysis, gas storage, chemical separations, photonics, and detections systems. Although promising, these micro- and nano-materials possess certain shortcomings that require further examination through fundamental studies. Towards overcoming these shortcomings, we proposed to investigate and drastically improve upon a series of key properties, specifically size and shape control, surface functionalization, volumetric surface area, and chemically specific gas sorption. Through these efforts, we have made significant discoveries, leading to the realization of biomolecule-functionalized nano-ICPs, unprecedentedly robust MOF topologies, and unique MOF structures with significant hydrogen and methane adsorption properties. Specifically, the novel DNA-ICP conjugates realized herein have demonstrated their utility as an in vitro gene regulatory tool, lending this construct to potential applications in therapeutics and diagnostics. Additionally, the carborane-MOF and MOP constructs described herein possess unique structural properties, making them key candidates for applications in selective gas sorption and boron neutron capture therapy (BNCT).


Descriptors :   *NANOPARTICLES , *ORGANOMETALLIC COMPOUNDS , *POLYMERIZATION , ADSORPTION , BIOCHEMISTRY , BIOMOLECULES , BORON , CELLS(BIOLOGY) , CHELATE COMPOUNDS , COLLOIDS , DEOXYRIBONUCLEIC ACIDS , GENES , GOLD , HYDROGEN , IN VITRO ANALYSIS , IONS , LIGANDS , METALS , METHANE , NEUTRON CAPTURE , STRUCTURAL PROPERTIES , SURFACE PROPERTIES , SYNTHESIS(CHEMISTRY) , TOPOLOGY


Subject Categories : Biochemistry
      Physical Chemistry
      Polymer Chemistry
      Miscellaneous Materials


Distribution Statement : APPROVED FOR PUBLIC RELEASE