Accession Number : ADA626553


Title :   Broadly Applicable Nanowafer Drug Delivery System for Treating Eye Injuries


Descriptive Note : Annual rept. 1 Sep 2014-31 Aug 2015


Corporate Author : BAYLOR COLL OF MEDICINE HOUSTON TX


Personal Author(s) : Pflugfelder, Stephen C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a626553.pdf


Report Date : Sep 2015


Pagination or Media Count : 42


Abstract : Eye injuries require immediate and effective treatment to prevent corneal opacification, neovascularization , irregularity and occasionally ulceration of the cornea, which can be potentially blinding. Eye injuries are generally treated with eye drops for 4-8 times per day, which may not be feasible in critically injured patients in intensive care. This research project aims to develop a nanowafer drug delivery system that can deliver the drug to the eye for longer periods of time to treat eye injuries and prevent potential loss of vision. During the second year of this project, the nanowafer fabrication and drug release in the eye have been optimized. The ability of the nanowafer to adherence and dissolution on the cornea has been optimized. The ability of the nanowafer to enable the drug molecules to diffuse into the corneal tissue for up to 2 days has been optimized. Presently studies are underway to evaluate the efficacy of Doxcycline, Dexamethasone, and Cyclosporine-A loaded nanowafers in ocular burn induced mouse model. These studies focus on quantification of the drug-nanowafer efficacy by time to epithelial healing using confocal fluorescence imaging and measurement of expression of relevant inflammatory mediator genes by real-time PCR.


Descriptors :   *EYE , *PHARMACOKINETICS , *WOUNDS AND INJURIES , BURNS(INJURIES) , CLINICAL MEDICINE , CORNEA , DELIVERY , DROPS , DRUGS , EPITHELIUM , FABRICATION , FLUORESCENT SCREENS , GENES , HEALING , IN VITRO ANALYSIS , IN VIVO ANALYSIS , INFLAMMATION , INTENSIVE CARE UNITS , MICE , NANOTECHNOLOGY , OPTIMIZATION , RECOVERY , TISSUES(BIOLOGY) , TRAUMA , ULCERS , WAFERS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology
      Biomedical Instrumentation and Bioengineering


Distribution Statement : APPROVED FOR PUBLIC RELEASE