Accession Number : ADA625712


Title :   Synthetic RNA Controllers for Programming Mammalian Cell Fate and Function


Descriptive Note : Final rept.


Corporate Author : STANFORD UNIV CA


Personal Author(s) : Smolke, Christina D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a625712.pdf


Report Date : 04 Nov 2015


Pagination or Media Count : 6


Abstract : The original objectives within Task 1 fell under several categories, including to: (i) extend the multi-input and multi-output control capabilities of RNA devices, (ii) develop multi-functional device platforms that support complex regulatory strategies, and (iii) develop an RNA device platform that controls posttranslational events. During the course of the DARPA contract we met the described goals of the first two objectives; however, the third objective, to develop an RNA device platform that controls posttranslational events, was not pursued after the first year of the agreement. This decision was based on progress made on this objective and the priorities of the program.


Descriptors :   *RIBONUCLEIC ACIDS , CELLS(BIOLOGY) , COMPUTER PROGRAMMING , CONTROL SYSTEMS , MAMMALS


Subject Categories : Organic Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE