Accession Number : ADA625406


Title :   Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle Inhibition


Corporate Author : MEDICAL UNIV OF SOUTH CAROLINA CHARLESTON


Personal Author(s) : Good, Cameron H ; Jhou, Thomas ; Burnham, Nathan


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a625406.pdf


Report Date : Sep 2015


Pagination or Media Count : 24


Abstract : The sublaterodorsal (SLD) nucleus is hypothesized to induce muscle atonia during rapid eye movement (REM) sleep. This was tested by injecting channelrhodopsin into the SLD of 5 rats, followed by a series of behavioral tests. Results confirmed our ability to rapidly induce muscle atonia following optogenetic stimulation of the SLD, suggesting that activation of the SLD is sufficient to cause a REM atonia like state.


Descriptors :   *EYE MOVEMENTS , ACTIVATION , MUSCLES , RAPID DEPLOYMENT , SKILLS , SLEEP , STIMULATION(GENERAL)


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE