Accession Number : ADA625341


Title :   Caffeine, Adenosine Receptors and Estrogen in Toxin Models of Parkinson's Disease


Descriptive Note : Annual rept. 1 Oct 2008-30 Sep 2009


Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON


Personal Author(s) : Schwarzschild, Michael A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a625341.pdf


Report Date : 01 Oct 2009


Pagination or Media Count : 115


Abstract : During the reporting period continued progress has been made toward our original Specific Aims (1-3) through approved Modified Aims (M1 and M2) of our project, Caffeine, adenosine receptors and estrogen in toxin models of Parkinson's disease (PD). The overarching hypothesis of the project is that multiple environmental protectants and toxins interact to influence of the health of the dopaminergic neurons lost in PD. To that end we are characterizing the interplay between environmental agents (e.g., pesticides, caffeine, estrogen) that are leading candidate modulators of PD risk. In Year 5 we obtained and reported evidence that the adenosine receptor blocker caffeine as well as specific genetic depletion of the A2A subtype of adenosine receptor are capable of conferring protection against neuron degeneration in chronic pesticide and genetic mouse models of PD. Moreover, we have demonstrated and published that adenosine A2A receptors expressed in forebrain neuron are critical for neuron degeneration in toxin model of PD. We also identified CSF levels of urate (an environmentally and genetically determined antioxidant) is a predictor of progression of PD.


Descriptors :   *ADENOSINE , *CAFFEINE , *ESTROGENS , *PARKINSONS DISEASE , *RECEPTOR SITES(PHYSIOLOGY) , MODELS , NERVE CELLS , NEUROTOXINS


Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE