Accession Number : ADA624585


Title :   Signal Propagation and Detection via Catalytically Immolative Biopolymer-Programmed Nanomaterials


Descriptive Note : Final rept. 1 Aug 2011-31 Jul 2014


Corporate Author : CALIFORNIA UNIV SAN DIEGO LA JOLLA


Personal Author(s) : Gianneschi, Nathan C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a624585.pdf


Report Date : 09 Feb 2015


Pagination or Media Count : 21


Abstract : Over the course of the funding of this proposal (August, 2011 to March 2013) we endeavored to pioneer the use of selective biochemical reactions and interactions for the preparation and manipulation of nanomaterials. Such interactions, especially those caused by selective enzymatic reactions, are vastly underutilized in materials science in general. This is surprising, given the fact that selective enzymatic reactions are responsible for the formation of some of the most extraordinary examples of well-defined nanomaterials and dynamic processes known from the formation of virus capsids, to the repair and replication of genetic information in living systems. We believe such approaches will enable the preparation of ever more complex nanomaterials capable of adapting to their environment and responding to stimuli in an autonomous fashion yielding switches and changes in their properties, chemistry and function. One particular focus of this program has been an effort to directly incorporate nucleic acids into polymeric materials through polymerization of nucleic acid monomers , and the incorporation of peptides and sensing elements into responsive nanomaterials in general. With the completion of this grant we believe we have achieved this, and published on this data accordingly. Excitingly, the work has lead in many new directions and we continue to push forward and make progress in these arenas.


Descriptors :   *DEOXYRIBONUCLEIC ACIDS , *NANOMATERIALS , *POLYMERIZATION , BIOCHEMISTRY , BIOLOGICAL DETECTION , BIOMOLECULES , CATALYSIS , CHEMICAL REACTIONS , ENZYMES , MONOMERS , NEOPLASMS , PEPTIDES , SIGNAL PROCESSING , STIMULI , SYNTHESIS(CHEMISTRY) , SYSTEMS BIOLOGY , TRANSMISSION ELECTRON MICROSCOPY , WAVE PROPAGATION


Subject Categories : Biochemistry
      Polymer Chemistry
      Miscellaneous Materials
      Atomic and Molecular Physics and Spectroscopy
      Biomedical Instrumentation and Bioengineering


Distribution Statement : APPROVED FOR PUBLIC RELEASE