Accession Number : ADA624347


Title :   Spinal Cord Repair with Engineered Nervous Tissue


Descriptive Note : Final rept. 30 Sep 2010-29 Jan 2014


Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA


Personal Author(s) : Smith, Douglas H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a624347.pdf


Report Date : Apr 2014


Pagination or Media Count : 19


Abstract : Spinal cord injury (SCI) exacts an enormous social and financial burden on society. As such, there has been considerable attention directed at finding treatment strategies, including development of tissue and cell transplant techniques. However, the current approaches do not adequately address the complexity of the injury site, such as lesion length and an environment that is usually non-permissive for axon regeneration. We have developed tissue engineered nerve grafts (TENGs) consisting of living dorsal root ganglia (DRG) and axons that can be stretch-grown to a length necessary to bridge extensive lesions. In current studies, we have optimized in vivo laminoplasty procedures, transplanted 5 mm-long stretch-grown constructs into a 5 mm-long lesion in the rat thoracic spinal cord, and have demonstrated survival of DRGs up to 6 weeks post-transplant. If successful, this approach will provide an alternative or additional means to repair large spinal lesions.


Descriptors :   *NERVE FIBERS , *SPINAL COLUMN , *SPINAL CORD , *SURGICAL TRANSPLANTATION , *TISSUES(BIOLOGY) , ATTENTION , GANGLIA , IN VIVO ANALYSIS , LENGTH , LESIONS , LIFE(BIOLOGY) , NERVES , OPTIMIZATION , REGENERATION(PHYSIOLOGY) , REPAIR , STRATEGY , SURVIVAL(GENERAL) , THORAX , TRANSPLANTATION , WOUNDS AND INJURIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE